[Lab] first independent cagrilintide purity number i have seen
Right: first independent cagrilintide purity number i have seen. I paid for this one myself, nobody sent me anything, and the receipts are in the comments. The engineering problem was duration: native amylin is short-acting and aggregation-prone. A long-acting analogue suitable for weekly administration is what makes…
The tolerability tables were more informative than the headline numbers, which is usually the case and never how it gets summarised.
Yes. The combination is where the interesting effect sizes are, and the monotherapy arms read very differently.
Correcting myself upthread: I gave the 4-week figure and the paper reports 50 weeks.
Complementary mechanisms are the rationale for pairing: satiety signalling alongside incretin signalling, rather than more agonism at the same receptor.
Yes. Anyone reading this board should hold their conclusions loosely until phase 3 reports.