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CagriSema — my 2-week log, condensed into one table

Question Cold Box ×7 Well Actually ×2

CagriSema — my 2-week log, condensed into one table. I have gone back and forth on this for months.

Carried an assumption over from the tirzepatide board and was corrected within an hour. Deserved.

Dosing intuitions from the GLP-1 boards do not transfer. Different receptor family, different exposure-response, and no published schedule for members to reason from.

Sent a vial to VendorInvestigate because there was almost nothing on file for this compound. 98.0% against a claimed 97.5%, and I posted it because the log needs entries.

Ask me anything specific. Anything general I will probably get wrong.

2,132 up / 268 down89% upvoted31 commentsid 1bab0q30 Dec 2024

31 comments

4 in this archive, depth 2

best — the order this archive was captured in

u/forest_plot_fionastats247 points·1 year ago

The honest state of the evidence on this board, since somebody should write it down.

Published clinical data exists and is genuinely interesting, particularly in combination. Independent purity data from members is thin — a handful of results across the whole site, against hundreds for the older molecules. Nothing containing this compound is approved as a standalone product, and research-use-only material is not approved for human use.

What follows practically: buy small if you buy at all, test what you get and post the result, and treat confident rankings against established compounds as the extrapolation they are. The board gets better as the log fills, and right now the log is nearly empty.

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u/sanne_laurent71 points·1 year ago·edited

Is there any independent purity data on this compound that you have seen?

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u/lucia_bruun235 points·1 year ago

The tolerability tables were more informative than the headline numbers, which is usually the case and never how it gets summarised.

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u/milos_vestergaardOP95 points·1 year ago

Bought small deliberately because the evidence base is thin. That felt like the only defensible approach.

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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