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c/cagrilintide·posted 10 months ago by u/milos_vestergaard

[Discussion] we are measuring amylin at the wrong time and calling it noise

Discussion Clean Column ×1 Cold Box ×3

we are measuring amylin at the wrong time and calling it noise. Making the case below, and I expect to lose some of it in the comments.

Bought small deliberately because the evidence base is thin. That felt like the only defensible approach.

Asked a question here that turned out to be based on a mechanism confusion. Three people untangled it patiently.

Kept a log purely because so few people are logging this one. It is one person and it is not data.

Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.

2,015 up / 104 down95% upvoted41 commentsid 1ar03g1 Oct 2025

41 comments

5 in this archive, depth 2

best — the order this archive was captured in

u/milos_vestergaard-16 points·10 months ago

Nothing containing this compound is approved as a standalone product, and research-use-only material is not approved for human use.

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u/milos_vestergaardOP1 point·10 months ago

Sent a vial to VendorInvestigate because there was almost nothing on file for this compound. 97.6% against a claimed 97.0%, and I posted it because the log needs entries.

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u/declared_value_dv139 points·10 months ago

the interesting data is the combination, not the monotherapy

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u/ms_fragmenter0 points·9 months ago

Push back: the evidence base here is thin enough that a confident ranking against the established compounds is not supportable.

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About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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