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c/cagrilintide·submitted 3 months ago by u/sequence_checker

[Meta] proposal — a flair for co-agonism posts

Discussionbranch of 6 comments

proposal — a flair for co-agonism posts — with the counter-argument included, because I find it fairly persuasive. Sent a vial to VendorInvestigate because there was almost nothing on file for this compound. 99.6% against a claimed 99.0%, and I posted it because the log needs entries. Combination and monotherapy arms…

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6 comments, started 3 months ago
u/niels_norgaard93 points·3 months ago

long-acting amylin is the whole point of the molecule

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u/rekha_mwangi26 points·3 months ago

long-acting amylin is the whole point of the molecule

Disagreeing with this line: that figure is from a combination arm and is being quoted as monotherapy.

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u/wrong_network_w-10 points·3 months ago

Which trial and which readout?

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[removed]1 point·3 months ago

[removed by moderator]

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u/pancreatitis_scare52 points·3 months ago

Read the combination paper twice before saying anything here. The monotherapy and combination arms tell genuinely different stories.

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u/rafael_krastev42 points·3 months ago

Careful — that is a dosing intuition carried over from another board and there is no basis for it here.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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