u/gustav_solberg

the MHRA supply notices are published, read them before the panic threads

Agreed — non-peptide is the fact that everything else follows from, including the manufacturing and the analytics.

Correction: that threshold is your ICB’s, not a national one. They differ and they change by year.

A shoulder that does not baseline-resolve cannot be quantified honestly. You can report it as an unresolved shoulder, which is useful information, or you can develop the method until it resolves.

Sceptical of the mechanism you are proposing. Gastric emptying slows, it does not stop, and the timings you describe do not follow from it.

Carryover from a previous high-concentration injection looks exactly like a small impurity. The blank injection is four minutes and it removes the ambiguity entirely.

Week 95: 25kg down, fatigue basically gone since about week 7, and the honest headline is that nothing dramatic happened. It was boring and it worked.

What dose and how many weeks at it before this started?

Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.