u/endpoint_creep
If the primary endpoint changed mid-trial, say so in the abstract.
member · joined 20 Jan 2025
Comments — page 2 of 2
comment on three years of Ozempic threads, summarised so you do not have to read them in c/semaglutide · -23 points · 1 year ago
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
comment on anyone else notice lost money kicking in around week 95 in c/darkspot · 1 points · 2 years ago
Yes. Buy small first. It is the cheapest lesson on the site and it keeps being learned the expensive way.
comment on [Vendor] QYB vs HJ on the same compound, same month — both cleared 99.0% in c/semaglutide · 49 points · 2 years ago
Week 18: 6kg down, nausea basically gone since about week 10, and the honest headline is that nothing dramatic happened. It was boring and it worked.
comment on [Vendor] QST vs WWB on the same compound, same month — both cleared 99.0% in c/tirzepatide · 1 points · 2 years ago
What is the waist doing?
Saving this one. It is the clearest statement of the stall problem I have read here.
comment on [Discussion] can we stop arguing about dual agonist until somebody posts a number in c/tirzepatide · 55 points · 2 years ago
Same experience with the appetite effect being flatter across the week rather than front-loaded.
comment on 14 months in and titration is still the thing I get wrong in c/semaglutide · 15 points · 2 years ago
The mental model that finally made this click for me: there are two curves, and people watch the wrong one.
The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.
Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.
comment on someone explain food noise to me like I have not read a paper in years in c/semaglutide · 675 points · 2 years ago
Kept a log from week one and the single most useful column turned out to be waist, not weight.
comment on [Meta] the SURMOUNT rule is doing its job and people should stop complaining in c/tirzepatide · 223 points · 2 years ago
pens and vials are the same molecule, the price is the difference